While estrogen is produced by the ovaries, it mainly acts on the vagina, uterus, breasts, bone, skin and the female distribution of fatty deposits in the body. After menses cease, around age 51 or 52, in what we call the menopause, there are subtle changes that gradually become more pronounced. Without estrogen replacement the vagina begins to shrink and the normal rippled contour of the vaginal wall becomes thinner, … [Read more...]